protective effects of withania somnifera root on inflammatory markers and insulin resistance in fructose-fed rats
نویسندگان
چکیده
background: we investigated the effects of withania somnifera root (ws) on insulin resistance, tumor necrosis factor α (tnf-α), and interleukin-6 (il-6) in fructose-fed rats. methods: forty-eight wistar-albino male rats were randomly divided into four groups (n=12); group i as control, group ii as sham-treated with ws by 62.5mg/g per diet, group iii fructose-fed rats received 10%w/v fructose, and group iv fructose- and ws-fed rats. after eight weeks blood samples were collected to measure glucose, insulin, il-6, and tnf-α levels in sera. results: blood glucose, insulin, homeostasis model assessment for insulin resistance (homa-r), il-6, and tnf-α levels were all significantly greater in the fructose-fed rats than in the controls. treatment with ws significantly (p < 0.05) inhibited the fructose-induced increases in glucose, insulin, homa-r, il-6, and tnf-α. conclusion: our data suggest that ws normalizes hyperglycemia in fructose-fed rats by reducing inflammatory markers and improving insulin sensitivity.
منابع مشابه
Protective Effects of Withania somnifera Root on Inflammatory Markers and Insulin Resistance in Fructose-Fed Rats
Background: We investigated the effects of Withania somnifera root (WS) on insulin resistance, tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6) in fructose-fed rats. Methods: Forty-eight Wistar-Albino male rats were randomly divided into four groups (n=12); Group I as control, Group II as sham-treated with WS by 62.5mg/g per diet, Group III fructose-fed rats received 10%...
متن کاملProtective effects of Withania somnifera root on inflammatory markers and insulin resistance in fructose-fed rats.
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عنوان ژورنال:
reports of biochemistry and molecular biologyجلد ۳، شماره ۲، صفحات ۶۲-۶۷
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